This study aims to analyze the difference of learning outcomes between studentswho were taught physics using guided inquiry-based learning model experiments with real and virtual laboratory learning model compare to Instruction Direct Instruction (DI).This study was a quasi-experimental. The study population was students of class XI-IPA Methodist 1 High School Medan of the school year 2012/2013. Sampling technique using a cluster random sampling consisting of two classes with a total sample of 76 students. The data analysis performed by Two Way Anova. The results obtained that there are significant difference between the results of studying physics students taught using guided inquiry learning model based on real and virtual laboratory experimentation and students taught using direct learning model. It can be concluded that the Guided Inquiry learning model based on real and virtual laboratory experiments is better than direct instructional model in improving student learning outcomes physics. There is a significant interaction between guided inquiry learning model based on real and virtual laboratory experiments and direct instructional model regarding the level of activity of the physics students\u27 learning outcomes.
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